abstract：:It has now been more than 20years since the vitamin D receptor was identified in cells of the immune system. The immune system has now been established as an important target of vitamin D. Vitamin D receptor knockout and vitamin D deficient mice have a surplus of effector T cells that have been implicated in the patho...

journal_title：Archives of biochemistry and biophysics

authors： Cantorna MT

更新日期：2012-07-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Archives of biochemistry and biophysics

authors： Mohan SK,Rani SG,Chiu IM,Yu C

更新日期：2012-06-05 00:00:00

abstract：:The single cysteine residue of human serum albumin (HSA-SH) is the most abundant plasma thiol. HSA transports fatty acids (FA), a cargo that increases under conditions of diabetes, exercise or adrenergic stimulation. The stearic acid-HSA (5/1) complex reacted sixfold faster than FA-free HSA at pH 7.4 with the disulfid...

journal_title：Archives of biochemistry and biophysics

authors： Torres MJ,Turell L,Botti H,Antmann L,Carballal S,Ferrer-Sueta G,Radi R,Alvarez B

更新日期：2012-05-01 00:00:00

abstract：:Autophagy, a ubiquitous degradation pathway, is important for the survival and homeostasis of cells. Previous studies have demonstrated the role of autophagy in host defense against bacterial infection, but the importance of autophagy in the intestinal epithelium for the regulation of bacterial infection has not been ...

journal_title：Archives of biochemistry and biophysics

authors： Inoue J,Nishiumi S,Fujishima Y,Masuda A,Shiomi H,Yamamoto K,Nishida M,Azuma T,Yoshida M

更新日期：2012-05-01 00:00:00

abstract：:The appearance of a high molecular weight gelatinolytic enzyme (230 kDa) correlated with cartilage collagen loss in chick embryonic tibias cultured with lipopolysaccharide. This 230 kDa enzyme was purified and its activity was measured on synthetic and natural substrates. The enzyme was activated by aminophenylmercuri...

journal_title：Archives of biochemistry and biophysics

authors： Patchigolla RK,Knudson W,Schmid TM

更新日期：2012-04-01 00:00:00

abstract：:The stability of the Glossoscolex paulistus hemoglobin (HbGp), in two iron oxidation states (and three forms), as monitored by optical absorption, fluorescence emission and circular dichroism (CD) spectroscopies, in the presence of the chaotropic agent urea, is studied. HbGp oligomeric dissociation, denaturation and i...

journal_title：Archives of biochemistry and biophysics

authors： Carvalho FA,Santiago PS,Tabak M

更新日期：2012-03-01 00:00:00

abstract：:Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and degrades hypoxia inducible factor-α (HIF-α). Degradation of HIF-α by VHL is proposed to suppress tu...

journal_title：Archives of biochemistry and biophysics

authors： Lai Y,Song M,Hakala K,Weintraub ST,Shiio Y

更新日期：2012-02-15 00:00:00

abstract：:Both CYP158A1 and CYP158A2 are able to catalyze an oxidative C-C coupling reaction producing biflaviolin or triflaviolin in Streptomyces coelicolor A3(2). The substrate-bound crystal structures of CYP158A2 and CYP158A1 reveal that the side chain of Ile87 in CYP158A2 points to the active site contacting the distal flav...

journal_title：Archives of biochemistry and biophysics

authors： Zhao B,Bellamine A,Lei L,Waterman MR

更新日期：2012-02-15 00:00:00

abstract：:Macrophages rapidly engulf and remove apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune disease or inflammation. Recent developments reveal an important role in autophagy for clearance of apoptotic corpses. However, the relationship between autophagy and phagocytosis remains ...

journal_title：Archives of biochemistry and biophysics

authors： Zang L,Xu Q,Ye Y,Li X,Liu Y,Tashiro S,Onodera S,Ikejima T

更新日期：2012-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor alpha (PPARα) has been implicated in the pathogenesis of cardiac hypertrophy, although its mechanism of action remains largely unknown. To determine the effect of PPARα activation on endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and explore its molecular mechanisms, w...

journal_title：Archives of biochemistry and biophysics

authors： Le K,Li R,Xu S,Wu X,Huang H,Bao Y,Cai Y,Lan T,Moss J,Li C,Zou J,Shen X,Liu P

更新日期：2012-02-01 00:00:00

abstract：:Although differences in size of the right and left thyroid lobes are well defined, differences in morphology, follicles structure, cAMP production, thyrotropin receptor, and protein involved in cell signalling have not previously been reported. This study provides morpho-functional data of right and left thyroid lobes...

journal_title：Archives of biochemistry and biophysics

authors： Albi E,Curcio F,Spelat R,Lazzarini R,Loreti E,Ferri I,Ambesi-Impiombato FS

更新日期：2012-02-01 00:00:00

abstract：:While molecular adaptation to high temperature has been extensively studied, the effect of hydrostatic pressure on protein structure and enzymatic activity is still poorly understood. We have studied the influence of pressure on both the quaternary structure and enzymatic activity of the dodecameric TET3 peptidase fro...

journal_title：Archives of biochemistry and biophysics

authors： Rosenbaum E,Gabel F,Durá MA,Finet S,Cléry-Barraud C,Masson P,Franzetti B

更新日期：2012-01-15 00:00:00

abstract：:Juvenile hormone binding protein (JHBP) acts as a shuttle, carrying one of the most crucial hormones for insect development to target tissues. We have found that although the JHBP molecule does not contain tryptophan residues, it exhibits a weak fluorescence maximum near 420nm upon excitation at 315nm. Gel filtration ...

journal_title：Archives of biochemistry and biophysics

authors： Bystranowska D,Szewczuk Z,Lisowski M,Sitkiewicz E,Dobryszycki P,Ożyhar A,Kochman M

更新日期：2012-01-01 00:00:00

abstract：:A gold(III) compound [Au(C^N^C)(IMe)]CF(3)SO(3) (Gold III) has been reported to have anticancer properties as it is able to reduce topoisomerase IB activity in vitro and suppress tumor growth in nude mice model. Here we have investigated the mechanism of inhibition of human topoisomerase IB activity by this compound, ...

journal_title：Archives of biochemistry and biophysics

authors： Castelli S,Vassallo O,Katkar P,Che CM,Sun RW,Desideri A

更新日期：2011-12-15 00:00:00

abstract：:FHRE-Luc is a promoter reporter construct that is widely used to assess the activity of FoxO (forkhead box, class O) transcription factors. We here demonstrate that this promoter construct responds to exposure of HepG2 human hepatoma cells to known agonists of the aryl hydrocarbon receptor (AhR), 3-methylcholanthrene,...

journal_title：Archives of biochemistry and biophysics

authors： Eckers A,Sauerbier E,Anwar-Mohamed A,Hamann I,Esser C,Schroeder P,El-Kadi AO,Klotz LO

更新日期：2011-12-15 00:00:00

abstract：:In the present study, the activity of Topoisomerase IIβ (TopoIIβ) is evaluated during peroxide induced double stranded DNA breaks (DSBs) repair in primary neurons. The results showed that the TopoIIβ levels were enhanced during recovery from peroxide mediated damage (PED) along with Ku70, PARP-1, pol beta, and WRN hel...

journal_title：Archives of biochemistry and biophysics

authors： Mandraju R,Chekuri A,Bhaskar C,Duning K,Kremerskothen J,Kondapi AK

更新日期：2011-12-15 00:00:00

abstract：:The amino acid L-lysine is synthesized in Saccharomyces cerevisiae via the α-aminoadipate pathway. An as yet unidentified PLP-containing aminotransferase is thought to catalyze the formation of α-aminoadipate from α-ketoadipate in the L-lysine biosynthetic pathway that could be the yeast Aro8 gene product. A screen of...

journal_title：Archives of biochemistry and biophysics

authors： Karsten WE,Reyes ZL,Bobyk KD,Cook PF,Chooback L

更新日期：2011-12-01 00:00:00

abstract：:Hydrogen peroxide triggers a redox cycle between methemoglobin and ferrylhemoglobin, leading to protein inactivation and oxygen evolution. In the present paper, the catalase-like oxygen production by human methemoglobin in the presence of H(2)O(2) was kinetically characterized with a Clark-type electrode. Progress cur...

journal_title：Archives of biochemistry and biophysics

authors： González-Sánchez MI,García-Carmona F,Macià H,Valero E

更新日期：2011-12-01 00:00:00

abstract：:Application of nanosecond pulsed electric fields (nsPEFs) has attracted attention as a unique tool in life sciences, especially for cancer therapy, but the molecular mechanism of its action on living organisms is yet to be fully elucidated. Here, we report a transient activation of signaling pathways involving mitogen...

journal_title：Archives of biochemistry and biophysics

authors： Morotomi-Yano K,Akiyama H,Yano K

更新日期：2011-11-01 00:00:00

abstract：:MICALs form a conserved multidomain protein family essential for cytoskeletal rearrangements. To complement structural information available, we produced the FAD-containing monooxygenase-like domain of human MICAL-1 (MICAL-MO) in forms differing for the presence and location of a His-tag, which only influences the pro...

journal_title：Archives of biochemistry and biophysics

authors： Zucchini D,Caprini G,Pasterkamp RJ,Tedeschi G,Vanoni MA

更新日期：2011-11-01 00:00:00

abstract：:Although the relationship between hypercholesterolemia and oxidative stress has been extensively investigated, direct evidence regarding to the roles of cholesterol accumulation in the generations of reactive oxygen species (ROS) and apoptotic cell death under oxidative stress is lack. In this study, we investigated p...

journal_title：Archives of biochemistry and biophysics

authors： Lee W,Xu M,Li Y,Gu Y,Chen J,Wong D,Fung PC,Shen J

更新日期：2011-10-01 00:00:00

abstract：:Saccharopine dehydrogenase catalyzes the NAD-dependent oxidative deamination of saccharopine to l-lysine and α-ketoglutarate. Lysine 99 is within hydrogen-bond distance to the α-carboxylate of the lysine substrate and D319 is in the vicinity of the carboxamide side chain of NADH. Both are conserved and may be importan...

journal_title：Archives of biochemistry and biophysics

authors： Ekanayake DK,West AH,Cook PF

更新日期：2011-10-01 00:00:00

abstract：:Dideoxyosones (DDOs) are intermediates in the synthesis of advanced glycation endproducts (AGEs), such as pentosidine and glucosepane. Although the formation of pentosidine and glucosepane in the human lens has been firmly established, the formation of DDOs has not been demonstrated. The aim of this study was to devel...

journal_title：Archives of biochemistry and biophysics

authors： Linetsky M,Kaid Johar SR,Meltretter J,Padmanabha S,Parmar T,Vasavada AR,Pischetsrieder M,Nagaraj RH

更新日期：2011-10-01 00:00:00

abstract：:The interactions between various dietary cancer chemopreventive phytochemicals in drug transporter functions are not well studied. In this study, the effects of genistein and resveratrol on the multidrug resistance protein 2 (MRP2) expression and the underlying molecular mechanisms were investigated using HepG2-C3 cel...

journal_title：Archives of biochemistry and biophysics

authors： Kim JH,Chen C,Tony Kong AN

更新日期：2011-08-15 00:00:00

abstract：:We recently cloned a rat brain agmatinase-like protein (ALP) whose amino acid sequence greatly differs from other agmatinases and exhibits a LIM-like domain close to its carboxyl terminus. The protein was immunohistochemically detected in the hypothalamic region and hippocampal astrocytes and neurons. We now show that...

journal_title：Archives of biochemistry and biophysics

authors： Castro V,Fuentealba P,Henríquez A,Vallejos A,Benítez J,Lobos M,Díaz B,Carvajal N,Uribe E

更新日期：2011-08-01 00:00:00

abstract：:Magnesium, the second most abundant cellular cation after potassium, is essential to regulate numerous cellular functions and enzymes, including ion channels, metabolic cycles, and signaling pathways, as attested by more than 1000 entries in the literature. Despite significant recent progress, however, our understandi...

journal_title：Archives of biochemistry and biophysics

authors： Romani AM

更新日期：2011-08-01 00:00:00

abstract：:Ceramidases play a critical role in generating sphingosine-1-phosphate by hydrolyzing ceramide into sphingosine, a substrate for sphingosine kinase. In order to elucidate its transcriptional regulation, we identify here a putative promoter region in the 5'-UTR of the human neutral CDase (nCDase) gene. Using human geno...

journal_title：Archives of biochemistry and biophysics

authors： O'Neill SM,Yun JK,Fox TE,Kester M

更新日期：2011-07-01 00:00:00

abstract：:Oridonin triggers apoptosis of cancer cells and was suggested as anticancer agent. Oridonin is partially effective through mitochondrial depolarization and partially by modifying gene expression. Erythrocytes lack mitochondria and nuclei but may undergo eryptosis, a suicidal cell death characterized by cell shrinkage ...

journal_title：Archives of biochemistry and biophysics

authors： Jilani K,Qadri SM,Zelenak C,Lang F

更新日期：2011-07-01 00:00:00

abstract：:The role of 1,25(OH)(2)D(3) on the intestinal NCX activity was studied in vitamin D-deficient chicks (-D) as well as the hormone effect on NCX1 protein and gene expression and the potential molecular mechanisms underlying the responses. Normal, -D and -D chicks treated with cholecalciferol or 1,25(OH)(2)D(3) were empl...

journal_title：Archives of biochemistry and biophysics

authors： Centeno V,Picotto G,Pérez A,Alisio A,Tolosa de Talamoni N

更新日期：2011-05-15 00:00:00

abstract：:Secreted frizzled-related protein (sFRP)-1 is a Wnt antagonist that inhibits breast carcinoma cell motility, whereas the secreted glycoprotein thrombospondin-1 stimulates adhesion and motility of the same cells. We examined whether thrombospondin-1 and sFRP-1 interact directly or indirectly to modulate cell behavior. ...

journal_title：Archives of biochemistry and biophysics

authors： Martin-Manso G,Calzada MJ,Chuman Y,Sipes JM,Xavier CP,Wolf V,Kuznetsova SA,Rubin JS,Roberts DD

更新日期：2011-05-15 00:00:00

abstract：:Pasteurella multocida is a pathogen of veterinary and medical importance. Here, we report the 1.85Å resolution crystal structure of the class C acid phosphatase from this organism (denoted rPmCCAP). The structure shows that rPmCCAP exhibits the same haloacid dehalogenase fold and dimeric assembly as the class C enzyme...

journal_title：Archives of biochemistry and biophysics

authors： Singh H,Malinski TJ,Reilly TJ,Henzl MT,Tanner JJ

更新日期：2011-05-01 00:00:00

abstract：:Oxalate oxidase (E.C. 1.2.3.4) catalyzes the oxygen-dependent oxidation of oxalate to carbon dioxide in a reaction that is coupled with the formation of hydrogen peroxide. Although there is currently no structural information available for oxalate oxidase from Ceriporiopsis subvermispora (CsOxOx), sequence data and ho...

journal_title：Archives of biochemistry and biophysics

authors： Moussatche P,Angerhofer A,Imaram W,Hoffer E,Uberto K,Brooks C,Bruce C,Sledge D,Richards NG,Moomaw EW

更新日期：2011-05-01 00:00:00

abstract：:Modification/chlorination of high-density lipoprotein (HDL) by hypochlorous acid (HOCl), formed by the myeloperoxidase-H₂O₂-chloride system of activated phagocytes, converts an anti-atherogenic lipoprotein into a pro-inflammatory lipoprotein particle. Chlorinated HDL is present in human lesion material, binds to and i...

journal_title：Archives of biochemistry and biophysics

authors： Rossmann C,Rauh A,Hammer A,Windischhofer W,Zirkl S,Sattler W,Malle E

更新日期：2011-05-01 00:00:00

abstract：:Ultradian clock-coupled respiratory oscillation (UCRO) in an aerobic continuous culture of Saccharomyces cerevisiae S288C is principally regulated by control of certain redox reactions of energy metabolism. It is also modulated by the metabolism of storage carbohydrates during adaptation to environmental change. Howev...

journal_title：Archives of biochemistry and biophysics

authors： Ouyang Y,Xu Q,Mitsui K,Motizuki M,Xu Z

更新日期：2011-05-01 00:00:00

abstract：:The skin is the largest organ of the body that produces a flexible and self-repairing barrier and protects the body from most common potentially harmful physical, environmental, and biological insults. Solar ultraviolet (UV) radiation is one of the major environmental insults to the skin and causes multi-tiered cellul...

journal_title：Archives of biochemistry and biophysics

authors： Afaq F

更新日期：2011-04-15 00:00:00

abstract：:Because angiogenesis underlies the pathogenesis of numerous conditions (cancer, psoriasis, macular degeneration), there is a pressing need for continued investigations into angiogenic signaling and potential drug targets. Antiangiogenic agents can be classified as either direct or indirect. Direct antiangiogenics act ...

journal_title：Archives of biochemistry and biophysics

authors： Berrios RL,Arbiser JL

更新日期：2011-04-15 00:00:00

abstract：:A new method for normal mode analysis is reported for all-atom structures using molecular geometry restraints (MGR). Similar to common molecular mechanics force fields, the MGR potential contains short- and long-range terms. The short-range terms are defined by molecular geometry, i.e., bond lengths, angles and dihedr...

journal_title：Archives of biochemistry and biophysics

authors： Lu M,Ma J

更新日期：2011-04-01 00:00:00

abstract：:Interactions between loops 2, 2' and 4, known as the loop bundle, stabilize the active site of caspase-3. Loop 4 (L4) is of particular interest due to its location between the active site and the dimer interface. We have disrupted a salt bridge between K242 and E246 at the base of L4 to determine its role in overall c...

journal_title：Archives of biochemistry and biophysics

authors： Walters J,Swartz P,Mattos C,Clark AC

更新日期：2011-04-01 00:00:00

abstract：:Plasminogen activator inhibitor (PAI)-1 is a major fibrinolytic inhibitor. High PAI-1 is associated with increased renal and cardiovascular disease risk. Previous studies demonstrated PAI-1 down-regulation by 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), but the molecular mechanism remains unknown. Here we show that exposur...

journal_title：Archives of biochemistry and biophysics

authors： Chen Y,Kong J,Sun T,Li G,Szeto FL,Liu W,Deb DK,Wang Y,Zhao Q,Thadhani R,Li YC

更新日期：2011-03-15 00:00:00

abstract：:Taurine is the most abundant free amino acid in leukocytes and can react with HOBr to produce taurine bromamine (Tau-NHBr). The aim of this study was to assess the ability of Tau-NHBr to oxidize tryptophan, either free or as a residue in albumin. We have demonstrated that Tau-NHBr is a powerful oxidant for tryptophan....

journal_title：Archives of biochemistry and biophysics

authors： Ximenes VF,da Fonseca LM,de Almeida AC

更新日期：2011-03-15 00:00:00